哈勒姆油
1924 年,Haarlem Oil 已在法國使用。 它有 Vidal 的專著,Alexandre Commission,Star Monograph 1981 看過。
The matter of sulfured terpenes, in which the properties are that of the components, oxides of organic sulfur, terpene essence from turpentine. A strong antiseptic action linked to the properties of turpentine essence.
大量分泌物,尤其是與硫有關的支氣管分泌物,已被證實具有修飾作用。
The diffusion of genuine Haarlem Oil is large in the organism, it as experimentally shown by pharmacological studies. Its benefits are aimed at the digestive absorption, biliary elimination, tissue distribution, constant plasma and excretion of S35 in rats. After a unique oral dose of Haarlem Oil with therapeutic dose of 10mg/kg.
Jacquot教授(1984)的研究表明,重要的組織分佈在支氣管-肺組織水平早熟15分鐘零一個小時。 正如Jacquot教授(1986)的一項研究所報導的那樣,這種抗炎作用是實驗性的,它注意到超氧化物歧化酶(SOD)的作用顯著升高,這可能是由於血漿中的硫醇升高所致。 哈勒姆油中沒有毒性,這可以緩解三個已確定的事實。
The diffusion of sulfur and pine terpene is great in the organism, it show experimentally by pharmacological studies. Its benefits are aimed at digestive absorption, biliary elimination, tissue distribution, constant plasma and excretion of S35 in rats. After a single oral dose of Haarlem oil with the therapeutic dose of 10 mg / kg
哈勒姆油自上市以來未見中毒案例。
意外中毒的風險不存在,主要發生在兒童中。
哈勒姆油有兩種形式:
裝在10毫升的瓶子中
膠囊,一盒30粒,6.4g
由於產品的濃郁味道,一些孩子會咀嚼藥片並將其立即吐出。 因此,該特產被高度甜化。
臨床研究方法
用法用量:
Genuine Haarlem Oil is prescribe at a dose of 10mg per kilo for an initial cure of 10 days. Eventually, to repeat for 8 to 10 days per month, if necessary.
管理方式:
滴狀下摻入甜食。
患者選擇:
在提供信息並徵得父母同意後,有25名兒童接受了哈萊姆油的治療。
兒童年齡:
孩子們的年齡在5個月至8歲之間。
所有患者均在個人檔案中報告並在附表中綜合了各種病因性慢性支氣管炎的臨床症狀。
處方使用哈勒姆油,不包括任何其他改善粘液的治療方法。
備註:
值得注意的是,只有2例患者的評估結果允許其從非常積極的過敏原中緩解。
評論
根據對25名兒童的臨床研究報告的結果,證實了使用哈萊姆油治療慢性支氣管-肺部感染的興趣。
最近的出版物清楚地向我們表明,所謂的“粘液纖毛自動扶梯”的有效性不僅取決於上皮細胞的完整性,纖毛的協調和運動,還取決於粘液鼻的特徵。在反復發生支氣管-肺部感染的情況下,線和粘彈性會改變並降低。
因此,使用哈勒姆油的理由如下:
- 很長一段時間以來,人們就對它們的粘液修飾特性和肺部殺菌劑有了一定的了解。
- 沒有毒性。
最近在動物身上進行的實驗已經得到授權,並賦予人類生物利用度和相同的作用,並且硫在支氣管肺水平上具有重要的組織固定作用。
我們的研究基於對臨床症狀和進化的簡單觀察。 很難,根據 的意見,由於多種病因與慢性支氣管肺病理學的競爭以及復雜互補探索的事實,很難進行大規模的對照試驗來評估靈丹妙藥和粘液修飾的有效性。 出於這些原因,我們選擇了與其他產品相比的臨床評價和進化,目前建議用於治療這些症狀。
In 68% of the cases in our series, we observed since the first treatment of Haarlem Oil, the clarification and the disappearance of bronchial hyper-secretion, in less than one week. This confirms the positive rheological action of the antiseptic action of genuine Haarlem Oil. These actions continued with remnants after several weeks, in the majority of the cases. In 70% of children, for which the renewing of the treatment of Haarlem Oil was proposed monthly, effectiveness followed favorably, bringing a total recovery of chronic bronchial-pulmonary, in less than four months. We can measure the savings also realized by the multiple treatments previously used (particularly the repeated antibiotic treatments). In the other cases, 60% of which the monthly cures continue systematically or by request, the antiseptic action and clarification of tracheal-bronchitis secretion were shown. Haarlem Oil obtained the disappearance of all congestion symptoms during the long periods and has also significantly reduced the episodes of secondary infection, uniquely observed in children, in which the attack of chronic bronchial-pulmonary was considered as definitive.
巨噬細胞釋放白三烯是由於其支氣管構造作用,在空氣通道中的滯留而受到青睞。 由呼吸後遺症產生的氧氣的有毒代謝作用比未成熟的新生兒的抗氧化系統更為重要。
因此,對C. Jacquot的研究顯得十分必要。 它在動物身上證明了哈勒姆油的抗氧化活性。 生物體的主要抗氧化酶超氧化物歧化酶 (SOD) 的活性在哈勒姆油治癒的病例中明顯高於見證組。 這增加了血漿中硫醇基團的升高。
結論
哈勒姆油用於 25 名感染各種病因的慢性支氣管肺病的兒童,自第一次治療以來,在 68% 的病例中顯示出良好的效果,在每月更新治療的 70% 的病例中,支氣管分泌過多的臨床症狀減輕和消失。 這種作用明顯優於習慣性開出的粘液調節藥物。
It is desirable that the studies continue particularly at the pharmacological level, next to the antiseptic actions and classic mucus-modifications known of genuine Haarlem Oil. The antioxidant activity brought into evidence, the elevation of the activity of the Superoxide Dismutase (SOD), essential appearance in the prevention of pulmonary bronchial-dysplasia.